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KMID : 0361020230660100670
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Korean Journal of Otolaryngology - Head and Neck Surgery
2023 Volume.66 No. 10 p.670 ~ p.677
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Short-Term Efficacy and Safety of the Direct Triamcinolone Application Using Absorbable Nasal Packing in Anosmic Patients
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Jeong Jong-In
Shanshan Yang
Kim Hyo-Yeol
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Abstract
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Background and Objectives The most common treatment for olfactory dysfunction is theuse of glucocorticoids. However, using systemic glucocorticoids is limited due to systemicside effects, and topical glucocorticoids are less effective than systemic glucocorticoids. Theaim of this study is to evaluate short-term therapeutic effects of direct triamcinolone (TA) ap-plication using absorbable nasal packing material on anosmia patients.
Subjects and Method This was a retrospective study that evaluated patients who were di-agnosed with anosmia and treated with oral prednisolone (PD) pulse therapy or 2 times of a 20mg dose of TA impregnated absorbable nasal packing in both olfactory clefts. Information of thedemographic features, the self-reporting olfaction scores (visual analogue scale [VAS], 0-10),and the threshold, discrimination, identification (TDI) scores of Korean version of the Sniffin’stick test II were collected and analyzed.
Results The data of 72 patients were analyzed in this study: 30 patients were treated withTA nasal packing, and 42 patients with oral PD. In both group, VAS and TDI scores were sig-nificantly improved 2 weeks after treatment. The rate of significant olfactory improvement ofTA nasal packing group was higher than oral PD group (60.0% vs. 47.6%), but there was nostatistically significant difference ( p=0.300). There was no significant systemic adverse effectafter TA nasal packing treatments.
Conclusion Direct TA application using absorbable nasal packing is a possible treatment op-tion in anosmic patients.
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KEYWORD
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Adrenal cortex hormone, Anosmia, Smell, Nasal packing
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